Human Cytosolic 3α-Hydroxysteroid Dehydrogenases of the Aldo-keto Reductase Superfamily Display Significant 3β-Hydroxysteroid Dehydrogenase Activity
نویسندگان
چکیده
منابع مشابه
Human Cytosolic 3 -Hydroxysteroid Dehydrogenases of the Aldo-keto Reductase Superfamily Display Significant 3 -Hydroxysteroid Dehydrogenase Activity IMPLICATIONS FOR STEROID HORMONE METABOLISM AND ACTION*
The source of NADPH-dependent cytosolic 3 -hydroxysteroid dehydrogenase (3 -HSD) activity is unknown to date. This important reaction leads e.g. to the reduction of the potent androgen 5 -dihydrotestosterone (DHT) into inactive 3 -androstanediol (3 -Diol). Four human cytosolic aldo-keto reductases (AKR1C1– AKR1C4) are known to act as non-positional-specific 3 -/ 17 -/20 -HSDs. We now demonstrat...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2004
ISSN: 0021-9258
DOI: 10.1074/jbc.m313308200